Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a) (pTyr452) Antikörper

Details zu Produkt Nr. ABIN6267950
Target
Bindungsspezifität
pTyr452
18
17
15
15
15
14
13
9
6
4
4
4
4
4
3
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
156
141
123
11
6
3
3
2
2
2
2
2
1
1
1
Wirt
Kaninchen
149
48
Klonalität
Polyklonal
Konjugat
Unkonjugiert
13
9
7
7
7
7
7
7
7
6
6
5
3
3
3
3
3
1
Applikation
ELISA, Western Blotting (WB)
126
71
55
40
30
21
20
13
6
3
3
3
2
2
1
Optionen
Immunogen A synthesized peptide derived from human P85 alpha around the phosphorylation site of Tyr452
Isotyp IgG
Spezifität Phospho-P85 alpha(Tyr452) Antibody detects endogenous levels of P85 alpha only when phosphorylated at Tyr452
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung P85 alpha (PI3K p85a Antibody Abstract)
Hintergrund

Description: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).

Gene: PIK3R1

Molekulargewicht 85kDa
Gen-ID 5295
UniProt P27986
Pathways T-Zell Rezeptor Signalweg, Response to Growth Hormone Stimulus, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Hepatitis C, Protein targeting to Nucleus, VEGF Signaling
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a) (pTyr452) antibody (ABIN6267950) Western blot analysis of Phospho-P85 alpha(Tyr452) in lysates of NIH/3T3-Src, using P...