p53 Antikörper (Tumor Protein P53) (acLys381)

Details for Product anti-TP53 Antibody No. ABIN6267936
Target
Bindungsspezifität
acLys381
68
45
42
39
37
35
33
33
27
26
26
24
21
20
20
19
17
17
15
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15
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13
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2
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2
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2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
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Reaktivität
Human, Maus, Ratte
1189
338
318
180
79
59
59
31
17
16
16
12
10
5
4
4
4
4
3
3
2
2
2
2
1
1
1
Wirt
Kaninchen
873
347
7
2
1
1
1
Klonalität
Polyklonal
Konjugat
Dieser p53 Antikörper ist unkonjugiert
73
47
37
33
33
32
32
32
32
19
16
15
12
12
12
12
12
5
5
5
5
5
5
5
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5
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5
5
5
5
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
Applikation
ELISA, Western Blotting (WB)
852
413
382
294
233
193
181
155
76
50
48
34
32
25
21
18
15
15
14
9
6
3
3
2
2
2
1
1
1
1
1
1
1
1
Optionen
Immunogen A synthesized peptide derived from human Acetyl-p53 (K381)
Isotyp IgG
Spezifität Acetyl-p53 (K381) Antibody detects endogenous levels of Acetyl-p53 (K381)
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung Immunogen affinity purified
Target
Andere Bezeichnung p53 (TP53 Antibody Abstract)
Hintergrund

Description: Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis, the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492).

Gene: TP53

Molekulargewicht 43.7kDa
Gen-ID 7157
UniProt P04637
Pathways p53 Signalweg, MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagie
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Tumor Protein P53 (TP53) (acLys381) antibody (ABIN6267936) Western blot analysis of Acetyl-p53 (K381) in lysates of MDA-MB-435 UV, using Acetyl-...