Poly(A) Binding Protein, Cytoplasmic, Pseudogene 2 (PABPCP2) (pSer150) Antikörper

Details zu Produkt Nr. ABIN6267888
Target
Bindungsspezifität
pSer150
1
1
Reaktivität
Rind (Kuh), Human, Maus, Ratte
3
2
1
1
Wirt
Kaninchen
2
1
Klonalität
Polyklonal
Applikation
ELISA, Western Blotting (WB)
3
2
Optionen
Immunogen A synthesized peptide derived from human PABP2 around the phosphorylation site of Ser150
Isotyp IgG
Spezifität Phospho-PABP2(Ser150) Antibody detects endogenous levels of PABP2 only when phosphorylated at Ser150
Kreuzreaktivität Rind (Kuh), Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung PABP2 (PABPCP2 Antibody Abstract)
Hintergrund

Description: Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes (PubMed:11371506). Binds to poly(A) and to poly(G) with high affinity (By similarity). May protect the poly(A) tail from degradation (By similarity). Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484).

Gene: PABPN1

Molekulargewicht 50kDa
Gen-ID 8106
UniProt Q86U42
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Poly(A) Binding Protein, Cytoplasmic, Pseudogene 2 (PABPCP2) (pSer150) antibody (ABIN6267888) Western blot analysis of Phospho-PABP2(Ser150) in lysates of cos-7, using Phospho-PAB...