CYLD Antikörper (Cylindromatosis (Turban Tumor Syndrome)) (pSer422)

Details for Product anti-CYLD Antibody No. ABIN6267882
Target
Bindungsspezifität
pSer422
16
15
5
4
3
2
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
46
28
20
2
1
1
1
1
1
1
1
Wirt
Kaninchen
41
7
6
Klonalität
Polyklonal
Konjugat
Dieser CYLD Antikörper ist unkonjugiert
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
28
16
14
7
6
5
5
1
1
1
1
1
Optionen
Immunogen A synthesized peptide derived from human CYLD around the phosphorylation site of Ser422
Isotyp IgG
Spezifität Phospho-CYLD(Ser422) Antibody detects endogenous levels of CYLD only when phosphorylated at Ser422
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung CYLD (CYLD Antibody Abstract)
Hintergrund

Description: Deubiquitinase that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation (PubMed:12917689, PubMed:12917691). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane, this process does not depend on NF-kappa-B activation (By similarity). Also able to remove linear ('Met-1'-linked) polyubiquitin chains to regulate innate immunity: recruited to the LUBAC complex and, together with OTULIN, restricts linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (PubMed:26670046, PubMed:26997266).

Gene: CYLD

Molekulargewicht 108kDa
Gen-ID 1540
UniProt Q9NQC7
Pathways Apoptose, Activation of Innate immune Response
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Cylindromatosis (Turban Tumor Syndrome) (CYLD) (pSer422) antibody (ABIN6267882) Western blot analysis of Phospho-CYLD(Ser422) in lysates of 293?, using Phospho-CYLD(...