NEDD4 Antikörper (Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase) (pSer670) Primary Antibody
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- Target
- NEDD4
- Bindungsspezifität
- pSer670
- Reaktivität
- Human
- Wirt
- Kaninchen
- Klonalität
- Polyklonal
- Konjugat
- Dieser NEDD4 Antikörper ist unkonjugiert
- Applikation
- ELISA, Western Blotting (WB)
- Spezifität
- Phospho-NEDD4(Ser670) Antibody detects endogenous levels of NEDD4 only when phosphorylated at Ser670
- Kreuzreaktivität
- Human
- Aufreinigung
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
- Immunogen
- A synthesized peptide derived from human NEDD4 around the phosphorylation site of Ser670
- Isotyp
- IgG
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anti-Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase (NEDD4) (AA 1288-1319) antibody Primary Antibody
NEDD4 Reaktivität: Human, Maus FACS, IHC, ELISA, WB Wirt: Kaninchen Polyclonal unconjugated
anti-Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase (NEDD4) (AA 977-1007), (C-Term) antibody Primary AntibodyNEDD4 Reaktivität: Human, Maus FACS, IHC (p), WB Wirt: Kaninchen Polyclonal unconjugated
anti-Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase (NEDD4) (AA 1288-1319), (C-Term) antibody Primary AntibodyNEDD4 Reaktivität: Human, Maus FACS, IHC (p), WB Wirt: Kaninchen Polyclonal unconjugated
anti-Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase (NEDD4) antibody Primary AntibodyNEDD4 Reaktivität: Human, Maus FACS, IHC, WB Wirt: Kaninchen Polyclonal unconjugated
anti-Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase (NEDD4) (Middle Region) antibody Primary AntibodyNEDD4 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen WB Wirt: Kaninchen Polyclonal unconjugated
anti-Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase (NEDD4) (AA 861-890) antibody Primary AntibodyNEDD4 Reaktivität: Human, Maus, Ratte IF (p), IHC (p), WB Wirt: Kaninchen Polyclonal unconjugated
anti-Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase (NEDD4) antibody Primary AntibodyNEDD4 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
anti-Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase (NEDD4) (Internal Region) antibody Primary AntibodyNEDD4 Reaktivität: Human, Pferd, Makake ELISA, WB Wirt: Kaninchen Polyclonal unconjugated
anti-Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase (NEDD4) (Middle Region) antibody Primary AntibodyNEDD4 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
anti-Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase (NEDD4) (AA 960-1245) antibody Primary AntibodyNEDD4 Reaktivität: Human, Maus, Ratte ELISA, WB Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
- WB 1:500-1:2000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C.Stable for 12 months from date of receipt
- Haltbarkeit
- 12 months
-
- Target
- NEDD4
- Andere Bezeichnung
- NEDD4 (NEDD4 Antibody Abstract)
- Synonyme
- NEDD4-1, RPF1, AA959633, AL023035, AU019897, E430025J12Rik, Nedd4-1, Nedd4a, mKIAA0093, CG32184, CG42279, CG7555, DNedd4, Dmel\\CG42279, Dmel_CG32184, Dmel_CG7555, dNedd4, dNedd4-1, nedd4, GB16853, NEDD4, Nedd4, neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase, neural precursor cell expressed, developmentally down-regulated 4, CG42279 gene product from transcript CG42279-RJ, E3 ubiquitin-protein ligase Nedd-4, E3 ubiquitin-protein ligase NEDD4, NEDD4, Nedd4, LOC411723, LOC100457150, nedd4, LOC100547485
- Hintergrund
Description: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (PubMed:23644597). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046).
Gene: NEDD4
- Molekulargewicht
- 110kDa
- Gen-ID
- 4734
- UniProt
- P46934
- Pathways
- Notch Signalweg, Intracellular Steroid Hormone Receptor Signaling Pathway, Skeletal Muscle Fiber Development, Signaling Events mediated by VEGFR1 and VEGFR2