KAT2B Antikörper (K(lysine) Acetyltransferase 2B) (pTyr729)

Details for Product anti-KAT2B Antibody No. ABIN6267872
Target
Bindungsspezifität
pTyr729
15
13
8
7
5
4
4
3
2
2
2
2
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
85
54
34
9
7
5
3
3
3
2
2
2
1
Wirt
Kaninchen
72
14
Klonalität
Polyklonal
Konjugat
Dieser KAT2B Antikörper ist unkonjugiert
4
3
3
3
3
3
3
2
2
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
52
34
17
13
8
4
3
3
3
2
1
1
1
Optionen
Immunogen A synthesized peptide derived from human PCAF around the phosphorylation site of Tyr729
Isotyp IgG
Spezifität Phospho-PCAF(Tyr729) Antibody detects endogenous levels of PCAF only when phosphorylated at Tyr729
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung PCAF (KAT2B Antibody Abstract)
Hintergrund

Description: Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY, PLK4 and TBX5. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307).

Gene: KAT2B

Molekulargewicht 93kDa
Gen-ID 8850
UniProt Q92831
Pathways p53 Signalweg, Regulation of Carbohydrate Metabolic Process
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-K(lysine) Acetyltransferase 2B (KAT2B) (pTyr729) antibody (ABIN6267872) Western blot analysis of Phospho-PCAF(Tyr729) in lysates of A431, using Phospho-PCAF(...