SMURF1 Antikörper (SMAD Specific E3 Ubiquitin Protein Ligase 1) (pSer200)

Details for Product anti-SMURF1 Antibody No. ABIN6267854
Target
Bindungsspezifität
pSer200
16
15
12
9
8
8
7
7
7
4
2
2
2
2
1
1
1
Reaktivität
Human, Maus, Ratte
78
38
5
Wirt
Kaninchen
71
7
7
Klonalität
Polyklonal
Konjugat
Dieser SMURF1 Antikörper ist unkonjugiert
9
8
8
7
7
7
1
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
70
66
39
10
6
6
4
1
1
1
Optionen
Immunogen A synthesized peptide derived from human SMURF1 around the phosphorylation site of Ser200
Isotyp IgG
Spezifität Phospho-SMURF1(Ser200) Antibody detects endogenous levels of SMURF1 only when phosphorylated at Ser200
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung SMURF1 (SMURF1 Antibody Abstract)
Hintergrund

Description: E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404). Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Gene: SMURF1

Molekulargewicht 81kDa
Gen-ID 57154
UniProt Q9HCE7
Pathways Regulation of Cell Size
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) (pSer200) antibody (ABIN6267854) Western blot analysis of Phospho-SMURF1(Ser200) in lysates of MCF7, using Phospho-SMU...