TAZ Antikörper (Tafazzin) (pSer89)

Details for Product anti-TAZ Antibody No. ABIN6267838
Target
Bindungsspezifität
pSer89
15
12
11
10
5
4
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
104
36
35
3
3
2
2
2
2
2
1
1
Wirt
Kaninchen
89
9
7
1
1
Klonalität
Polyklonal
Konjugat
Dieser TAZ Antikörper ist unkonjugiert
7
6
6
3
3
3
3
3
3
3
3
3
2
2
2
2
2
Applikation
ELISA, Western Blotting (WB)
68
45
26
13
12
6
6
5
3
1
1
1
1
Optionen
Immunogen A synthesized peptide derived from human TAZ around the phosphorylation site of Ser89
Isotyp IgG
Spezifität Phospho-TAZ (Ser89) Antibody detects endogenous levels of TAZ only when phosphorylated at Ser89
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung TAZ (TAZ Antibody Abstract)
Hintergrund

Description: Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.

Gene: WWTR1

Molekulargewicht 44kDa
Gen-ID 25937
UniProt Q9GZV5
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Tafazzin (TAZ) (pSer89) antibody (ABIN6267838) Western blot analysis of Phospho-TAZ (Ser89) in lysates of NIH/3T3, using Phospho-TAZ...