TSC1 Antikörper (Tuberous Sclerosis 1) (pSer505)

Details for Product anti-TSC1 Antibody No. ABIN6267826
Target
Bindungsspezifität
pSer505
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21
18
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18
10
9
9
9
9
9
9
9
9
9
9
9
9
9
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9
9
9
9
8
8
5
4
3
3
3
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2
2
2
2
1
1
1
1
Reaktivität
Human, Maus, Ratte
228
175
85
28
2
1
1
Wirt
Kaninchen
355
24
7
1
Klonalität
Polyklonal
Konjugat
Dieser TSC1 Antikörper ist unkonjugiert
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38
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3
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Applikation
ELISA, Western Blotting (WB)
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253
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9
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2
1
1
Optionen
Immunogen A synthesized peptide derived from human TSC1 around the phosphorylation site of Ser505
Isotyp IgG
Spezifität Phospho-TSC1(Ser505) Antibody detects endogenous levels of TSC1 only when phosphorylated at Ser505
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung TSC1 (TSC1 Antibody Abstract)
Hintergrund

Description: In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400). Seems not to be required for TSC2 GAP activity towards RHEB (PubMed:15340059). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). Acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155).

Gene: TSC1

Molekulargewicht 150-170kDa
Gen-ID 7248
UniProt Q92574
Pathways RTK Signalweg, AMPK Signaling, Regulation of Cell Size, Tube Formation
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Tuberous Sclerosis 1 (TSC1) (pSer505) antibody (ABIN6267826) Western blot analysis of Phospho-TSC1(Ser505) in lysates of HT-1080, using Phospho-TS...