DKK1 Antikörper (Dickkopf Homolog 1 (Xenopus Laevis)) (pSer140)

Details for Product anti-DKK1 Antibody No. ABIN6267808
Target
Bindungsspezifität
pSer140
24
21
16
15
9
8
6
5
4
4
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus
154
52
43
21
6
6
5
4
3
3
3
3
2
2
1
1
1
1
1
Wirt
Kaninchen
143
15
7
1
Klonalität
Polyklonal
Konjugat
Dieser DKK1 Antikörper ist unkonjugiert
16
11
8
5
5
5
4
3
3
3
3
3
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
120
70
29
22
13
6
5
3
3
3
3
2
1
1
1
1
1
Optionen
Immunogen A synthesized peptide derived from human DKK1 around the phosphorylation site of Ser140
Isotyp IgG
Spezifität Phospho-DKK1(Ser140) Antibody detects endogenous levels of DKK1 only when phosphorylated at Ser140
Kreuzreaktivität Human, Maus
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung DKK1 (DKK1 Antibody Abstract)
Hintergrund

Description: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity).

Gene: DKK1

Molekulargewicht 28-40kDa
Gen-ID 22943
UniProt O94907
Pathways WNT Signalweg, Regulation of Muscle Cell Differentiation, Positive Regulation of fat Cell Differentiation
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) (pSer140) antibody (ABIN6267808) Western blot analysis of Phospho-DKK1(Ser140) in lysates of PC-3?, using Phospho-DKK1...