KIT Ligand Antikörper (KITLG) (AA 265-269)

Details for Product anti-KITLG Antibody No. ABIN6267796
Target
Bindungsspezifität
AA 265-269
16
10
8
7
5
5
4
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
Reaktivität
Human
142
67
49
6
4
4
3
3
2
2
2
1
1
1
1
1
Wirt
Kaninchen
159
27
18
1
Klonalität
Polyklonal
Konjugat
Dieser KIT Ligand Antikörper ist unkonjugiert
28
12
10
9
8
7
4
3
3
3
3
3
2
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
162
112
38
33
32
29
26
24
17
16
13
6
5
4
4
2
1
1
1
1
1
1
Optionen
Immunogen Peptide sequence around aa.265~269(E-K-E-R-E) derived from Human SCF.
Isotyp IgG
Spezifität The antibody detects endogenous level of total SCF protein.
Kreuzreaktivität Human
Reinigung The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Target
Andere Bezeichnung SCF (KITLG Antibody Abstract)
Hintergrund

Description: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.

Gene: KITLG

Molekulargewicht 25-38kDa
Gen-ID 4254
UniProt P21583
Pathways RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung
Applikations-hinweise WB 1:500-1:1000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Bilder
Image no. 1 for anti-KIT Ligand (KITLG) (AA 265-269) antibody (ABIN6267796) Western blot analysis of extracts from various samples, using SCF Antibody. Lane 1: 3...