LGR5 Antikörper (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5) (AA 490-494)

Details for Product anti-LGR5 Antibody No. ABIN6267788
Target
Bindungsspezifität
AA 490-494
24
8
5
4
4
3
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus
106
41
24
1
1
Wirt
Kaninchen
91
16
Klonalität
Polyklonal
Konjugat
Dieser LGR5 Antikörper ist unkonjugiert
4
3
3
3
3
3
3
1
1
1
1
1
1
1
1
1
1
1
1
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1
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
79
27
26
21
18
15
8
3
2
2
1
1
1
Optionen
Immunogen Peptide sequence around aa.490~494(K-I-S-N-Q) derived from Human LGR5(GPR49).
Isotyp IgG
Spezifität The antibody detects endogenous level of total LGR5(GPR49) protein.
Kreuzreaktivität Human, Maus
Reinigung The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Target
Andere Bezeichnung LGR5 (LGR5 Antibody Abstract)
Hintergrund

Description: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.

Gene: LGR5

Molekulargewicht 95kDa
Gen-ID 8549
UniProt O75473
Applikations-hinweise WB 1:500-1:1000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Bilder
Image no. 1 for anti-Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) (AA 490-494) antibody (ABIN6267788) Western blot analysis of extracts from Hela, 3T3 and HepG2 cells using LGR5(GPR49) An...