PR Domain Containing 1, with ZNF Domain (PRDM1) (AA 124-128) Antikörper

Details zu Produkt Nr. ABIN6267770
Target
Bindungsspezifität
AA 124-128
14
13
9
7
6
4
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
85
25
18
5
4
3
3
2
2
1
1
1
Wirt
Kaninchen
47
27
15
1
Klonalität
Polyklonal
Konjugat
Unkonjugiert
8
4
4
4
4
3
1
1
1
1
1
1
Applikation
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
82
57
20
14
7
6
4
4
3
2
2
2
1
1
Optionen
Immunogen Peptide sequence around aa.124~128(D-T-V-P-K) derived from Human Blimp-1
Isotyp IgG
Spezifität The antibody detects endogenous levels of total Blimp-1 protein.
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Target
Andere Bezeichnung Blimp-1 (PRDM1 Antibody Abstract)
Hintergrund

Description: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). Drives the maturation of B-lymphocytes into Ig secreting cells (PubMed:12626569). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (By similarity).

Gene: PRDM1

Molekulargewicht 95 100kDa
Gen-ID 639
UniProt O75626
Pathways Regulation of Muscle Cell Differentiation
Applikations-hinweise WB 1:500-1:1000 IF 1:100-400
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Bilder
Image no. 1 for anti-PR Domain Containing 1, with ZNF Domain (PRDM1) (AA 124-128) antibody (ABIN6267770) ABIN6267771 staining HEPG2 cells by ICC/IF. Cells were fixed with PFA and permeabiliz...
Image no. 2 for anti-PR Domain Containing 1, with ZNF Domain (PRDM1) (AA 124-128) antibody (ABIN6267770) Western blot analysis of extracts from JK and Raji cells using Blimp-1 Antibody