Myelin Basic Protein (MBP) (AA 291-295) Antikörper

Details zu Produkt Nr. ABIN6267768
Target
Bindungsspezifität
AA 291-295
25
15
15
15
10
8
7
7
6
5
4
4
4
4
4
4
4
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
193
82
71
38
22
18
15
13
10
8
6
6
6
5
3
2
2
2
1
1
Wirt
Kaninchen
137
67
12
11
5
1
1
Klonalität
Polyklonal
Konjugat
Unkonjugiert
12
10
10
4
4
4
4
4
4
3
3
3
3
3
3
3
2
1
Applikation
ELISA, Western Blotting (WB)
136
91
65
49
39
39
26
21
18
10
10
10
8
6
5
3
2
1
1
Optionen
Immunogen Peptide sequence around aa.291~295(G-G-R-D-S
Isotyp IgG
Spezifität The antibody detects endogenous level of total MBP(myelin basic protein) protein.
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Target
Andere Bezeichnung Myelin basic protein (MBP Antibody Abstract)
Hintergrund

Description: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.

Gene: MBP

Molekulargewicht 14~33kDa
Gen-ID 4155
UniProt P02686
Applikations-hinweise WB 1:500-1:1000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Bilder
Image no. 1 for anti-Myelin Basic Protein (MBP) (AA 291-295) antibody (ABIN6267768) Western blot analysis of extract from Rat brain, Mouse brain and Rat hippocampus Tiss...