FOXP1 Antikörper (Forkhead Box P1) (AA 669-673)

Details for Product anti-FOXP1 Antibody No. ABIN6267764
Target
Bindungsspezifität
AA 669-673
17
16
16
7
4
2
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
97
49
45
5
4
4
3
3
3
2
1
1
Wirt
Kaninchen
85
16
Klonalität
Polyklonal
Konjugat
Dieser FOXP1 Antikörper ist unkonjugiert
9
7
7
3
3
3
3
3
3
3
2
2
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
67
42
39
38
15
13
7
5
4
3
2
1
1
1
1
Optionen
Immunogen Peptide sequence around aa. 669~673 (D-E-P-V-N
Isotyp IgG
Spezifität The antibody detects endogenous level of total FOXP1 protein.
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Target
Andere Bezeichnung FOXP1 (FOXP1 Antibody Abstract)
Hintergrund

Description: Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program, the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity, may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence, the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions, repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18799727, PubMed:18347093). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis, the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093).

Gene: FOXP1

Molekulargewicht 82~90kDa
Gen-ID 27086
UniProt Q9H334
Pathways Chromatin Binding, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
Applikations-hinweise WB 1:500-1:1000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Bilder
Image no. 1 for anti-Forkhead Box P1 (FOXP1) (AA 669-673) antibody (ABIN6267764) Western blot analysis of extract from JK, Raji, Hela and 293 cells using FOXP1 Antibody