Ring Finger Protein 1 (RING1) (AA 35-39) Antikörper

Details zu Produkt Nr. ABIN6267758
Target
Bindungsspezifität
AA 35-39
10
8
7
4
4
3
2
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
64
19
18
7
6
6
6
4
4
3
3
3
Wirt
Kaninchen
42
23
Klonalität
Polyklonal
Konjugat
Unkonjugiert
4
2
2
2
2
2
2
2
2
2
2
2
Applikation
ELISA, Western Blotting (WB)
55
31
7
4
3
3
2
2
1
1
Optionen
Immunogen Peptide sequence around aa.35~39( I-A-V-S-P) derived from Human Ring1A.
Isotyp IgG
Spezifität The antibody detects endogenous level of total Ring1A protein.
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Target
Andere Bezeichnung Ring1A (RING1 Antibody Abstract)
Hintergrund

Description: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.

Gene: RING1

Molekulargewicht 58kDa
Gen-ID 6015
UniProt Q06587
Applikations-hinweise WB 1:500-1:1000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Bilder
Image no. 1 for anti-Ring Finger Protein 1 (RING1) (AA 35-39) antibody (ABIN6267758) Western blot analysis of extract from Hela cells using Ring1A Antibody