RAB5 Antikörper (RAB5A, Member RAS Oncogene Family) (AA 188-192)

Details for Product anti-RAB5A Antibody No. ABIN6267756
Target
Bindungsspezifität
AA 188-192
20
17
9
7
6
5
2
2
2
2
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
127
88
82
39
37
14
11
11
11
10
9
9
5
4
4
4
4
2
2
2
1
Wirt
Kaninchen
112
14
5
2
Klonalität
Polyklonal
Konjugat
Dieser RAB5 Antikörper ist unkonjugiert
9
6
5
4
4
4
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
109
66
51
40
38
28
18
13
7
5
4
4
2
1
Optionen
Immunogen Peptide sequence around aa.188~192( N-P-G-A-N) derived from Human Rab5.
Isotyp IgG
Spezifität The antibody detects endogenous level of total Rab5 protein.
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Target
Andere Bezeichnung Rab5 (RAB5A Antibody Abstract)
Hintergrund

Description: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity).

Gene: RAB5A

Molekulargewicht 25kDa
Gen-ID 5868
UniProt P20339
Pathways Smooth Muscle Cell Migration, Regulation of long-term Neuronal Synaptic Plasticity
Applikations-hinweise WB 1:500-1:1000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Bilder
Image no. 1 for anti-RAB5A, Member RAS Oncogene Family (RAB5A) (AA 188-192) antibody (ABIN6267756) Western blot analysis of extract from Hela, MCF and PC12 cells using Rab5 Antibody