HSD17B10 Antikörper (Hydroxysteroid (17-Beta) Dehydrogenase 10) (AA 253-527)

Details for Product anti-HSD17B10 Antibody No. ABIN6267742
Target
Bindungsspezifität
AA 253-527
10
6
5
4
4
3
2
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
69
28
22
4
3
3
3
Wirt
Kaninchen
54
11
7
Klonalität
Polyklonal
Konjugat
Dieser HSD17B10 Antikörper ist unkonjugiert
5
3
2
2
2
2
1
1
1
1
1
1
1
Applikation
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
60
28
26
17
16
13
9
3
2
1
1
1
1
1
Optionen
Immunogen Peptide sequence around aa.253~257(L-D-G-A-I)derived from Human ERAB.
Isotyp IgG
Spezifität The antibody detects endogenous level of total ERAB protein.
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Target
Andere Bezeichnung ERAB (HSD17B10 Antibody Abstract)
Hintergrund

Description: Mitochondrial dehydrogenase that catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone (PubMed:9553139, PubMed:23042678, PubMed:12917011, PubMed:18996107, PubMed:25925575, PubMed:28888424). Catalyzes the third step in the beta-oxidation of fatty acids (PubMed:9553139, PubMed:12917011, PubMed:18996107, PubMed:25925575, PubMed:28888424). Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids (PubMed:12917011). Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids (PubMed:12917011). By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD) (PubMed:9338779). Essential for structural and functional integrity of mitochondria (PubMed:20077426).

Gene: HSD17B10

Molekulargewicht 27kDa
Gen-ID 3028
UniProt Q99714
Applikations-hinweise WB 1:500-1:1000, IF/ICC 1:100-1:500
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Bilder
Image no. 1 for anti-Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) (AA 253-527) antibody (ABIN6267742) Western blot analysis of extract from JK, HUVEC, HepG2 and Hela cells using ERAB Anti...
Image no. 2 for anti-Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) (AA 253-527) antibody (ABIN6267742) Western blot analysis of extracts from mouse spleen, rat brain, using ERAB Antibody.
Image no. 3 for anti-Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) (AA 253-527) antibody (ABIN6267742) ABIN6267743 staining LOVO by IF/ICC. The sample were fixed with PFA and permeabilized...