Pyruvate Kinase M1/2 (PKM) (AA 405-409) Antikörper

Details zu Produkt Nr. ABIN6267740
Target
Bindungsspezifität
AA 405-409
24
19
19
18
15
15
8
8
8
7
7
7
6
5
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human
207
124
100
6
6
2
2
2
2
2
1
1
1
1
Wirt
Kaninchen
177
28
6
2
1
Klonalität
Polyklonal
Konjugat
Unkonjugiert
19
12
11
11
11
11
11
7
7
3
3
3
2
2
2
2
2
Applikation
ELISA, Western Blotting (WB)
135
79
52
26
26
22
18
10
8
6
4
3
3
2
2
1
1
1
1
Optionen
Immunogen Peptide sequence around aa.405~409(T-S-D-P-T) derived from Human PKM2.
Isotyp IgG
Spezifität The antibody detects endogenous levels of total PKM2 protein.
Kreuzreaktivität Human
Reinigung The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Target
Andere Bezeichnung PKM2 (PKM Antibody Abstract)
Hintergrund

Description: Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.

Gene: PKM

Molekulargewicht 60kDa
Gen-ID 5315
UniProt P14618
Applikations-hinweise WB 1:500-1:1000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Bilder
Image no. 1 for anti-Pyruvate Kinase M1/2 (PKM) (AA 405-409) antibody (ABIN6267740) Western blot analysis of extracts from HepG2 and 293 cells using PKM1/2 Antibody