N-Cadherin Antikörper (Cadherin 2) (AA 800-804)

Details for Product anti-CDH2 Antibody No. ABIN6267736
Target
Bindungsspezifität
AA 800-804
22
22
15
15
7
7
4
4
4
4
4
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
190
150
98
18
10
8
5
4
4
4
4
3
3
3
3
3
2
1
1
1
1
Wirt
Kaninchen
116
87
5
3
2
Klonalität
Polyklonal
Konjugat
Dieser N-Cadherin Antikörper ist unkonjugiert
23
6
5
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
1
Applikation
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
157
79
71
71
34
26
25
23
13
12
5
4
3
2
1
1
Optionen
Immunogen Peptide sequence around aa.800~804(A-I-K-P-V) derived from Human N-Cadherin.
Isotyp IgG
Spezifität The antibody detects endogenous level of total N-Cadherin protein.
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Target
Andere Bezeichnung N-Cadherin (CDH2 Antibody Abstract)
Hintergrund

Description: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells, cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity).

Gene: CDH2

Molekulargewicht 140kDa
Gen-ID 1000
UniProt P19022
Pathways Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Synaptic Membrane
Applikations-hinweise WB 1:500-1:1000 IHC 1:50-200 IF 1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Bilder
Image no. 1 for anti-Cadherin 2 (CDH2) (AA 800-804) antibody (ABIN6267736) Western blot analysis of extract from HT29 cells using N-Cadherin antibody.
Image no. 2 for anti-Cadherin 2 (CDH2) (AA 800-804) antibody (ABIN6267736) ABIN6267737 staining A549 cells by ICC/IF. Cells were fixed with PFA and permeabilize...
Image no. 3 for anti-Cadherin 2 (CDH2) (AA 800-804) antibody (ABIN6267736) ABIN6267737 at 1/100 staining human lung carcinoma tissue sections by IHC-P. The tiss...
Image no. 4 for anti-Cadherin 2 (CDH2) (AA 800-804) antibody (ABIN6267736) ABIN6267737 staining COLO205 cells by IF/ICC. The sample were fixed with PFA and perm...
Produkt verwendet in: Ai, Zhang, Gao, Qin, Zhong, Gu, Li, Qiao, Tian, Cui, Yang, Bi, Xiao, Chen, Liu, Zhou, Sun, Yang: "Sesquiterpene binding Gly-Leu-Ser/Lys-"co-adaptation pocket" to inhibit lung cancer cell epithelial-mesenchymal transition." in: Oncotarget, Vol. 8, Issue 41, pp. 70192-70203, 2018 (PubMed).

Huang, Song, Tao, Shao, Zeng, Xu, Qi, Sun: "Ovostatin 2 knockdown significantly inhibits the growth, migration, and tumorigenicity of cutaneous malignant melanoma cells." in: PLoS ONE, Vol. 13, Issue 4, pp. e0195610, 2018 (PubMed).