SOX2 Antikörper (SRY (Sex Determining Region Y)-Box 2) (AA 76-80)

Details for Product anti-SOX2 Antibody No. ABIN6267724
Target
Bindungsspezifität
AA 76-80
25
21
17
16
15
13
12
12
10
9
8
7
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus
238
102
74
14
11
11
10
8
8
8
6
5
5
5
2
2
1
1
1
Wirt
Kaninchen
189
57
4
Klonalität
Polyklonal
Konjugat
Dieser SOX2 Antikörper ist unkonjugiert
19
14
12
10
9
9
5
4
4
4
4
4
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
171
133
67
62
55
31
28
26
25
23
15
13
8
7
6
4
2
2
2
2
2
1
1
Optionen
Immunogen Peptide sequence around aa.76~80 (G-A-E-W-K) derived from SOX2
Isotyp IgG
Spezifität The antibody detects endogenous level of total SOX2 protein.
Kreuzreaktivität Human, Maus
Reinigung The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Target
Andere Bezeichnung SOX2 (SOX2 Antibody Abstract)
Hintergrund

Description: Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).

Gene: SOX2

Molekulargewicht 35kDa
Gen-ID 6657
UniProt P48431
Pathways Dopaminergic Neurogenesis, Sensory Perception of Sound, Stem Cell Maintenance, Cell RedoxHomeostasis
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Bilder
Image no. 1 for anti-SRY (Sex Determining Region Y)-Box 2 (SOX2) (AA 76-80) antibody (ABIN6267724) Western blot analysis of extracts from human Umbilical cord mesenchymal stem cell usi...