TWIST1 Antikörper (Twist Homolog 1 (Drosophila)) (AA 18-22)

Details for Product anti-TWIST1 Antibody No. ABIN6267722
Target
Bindungsspezifität
AA 18-22
15
9
8
6
5
5
4
3
3
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
88
41
38
4
4
4
3
2
2
2
1
1
1
1
Wirt
Kaninchen
52
32
4
Klonalität
Polyklonal
Konjugat
Dieser TWIST1 Antikörper ist unkonjugiert
4
3
3
3
3
3
3
2
2
1
1
1
1
1
1
1
1
Applikation
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
58
32
14
13
12
10
8
7
5
4
4
2
2
2
1
Optionen
Immunogen Peptide sequence around aa.18~22(S-N-S-E-E) derived from Human Twist1
Isotyp IgG
Spezifität The antibody detects endogenous levels of total Twist1 protein.
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Target
Andere Bezeichnung Twist1 (TWIST1 Antibody Abstract)
Hintergrund

Description: Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer (By similarity).

Gene: TWIST1

Molekulargewicht 29 kDa
Gen-ID 7291
UniProt Q15672
Pathways p53 Signalweg, Proton Transport, Tube Formation, Negative Regulation of Transporter Activity
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use
Bilder
Image no. 1 for anti-Twist Homolog 1 (Drosophila) (TWIST1) (AA 18-22) antibody (ABIN6267722) Western blot analysis of extracts from JK, Raji and HL-60 cells using Twist1 Antibody
Image no. 2 for anti-Twist Homolog 1 (Drosophila) (TWIST1) (AA 18-22) antibody (ABIN6267722) ABIN6267723 staining 293T by IF/ICC. The sample were fixed with PFA and permeabilized...
Produkt verwendet in: Yi, Shen, Zhao, Shao, Liu, Cui, Wang, Wang, Guo, Kang, Lv, Xing, Zhang: "Inflammation-mediated SOD-2 upregulation contributes to epithelial-mesenchymal transition and migration of tumor cells in aflatoxin G1-induced lung adenocarcinoma." in: Scientific reports, Vol. 7, Issue 1, pp. 7953, 2018 (PubMed).

Meng, Chen, Han, Qian, Wang, Zhong, Qin, Zhang, Gao, Lei, Yang, Yang, Zhang, Liu, Liu, Zhou, Sun, Yang: "Twist1 Regulates Vimentin through Cul2 Circular RNA to Promote EMT in Hepatocellular Carcinoma." in: Cancer research, Vol. 78, Issue 15, pp. 4150-4162, 2018 (PubMed).

Meng, Chen, Lei, Han, Zhong, Wang, Liu, Gao, Zhang, Tan, Liu, Zhou, Sun, Yang: "Hsp90β promotes aggressive vasculogenic mimicry via epithelial-mesenchymal transition in hepatocellular carcinoma." in: Oncogene, 2018 (PubMed).

Yang, Lian, Sun, Qi, Ding, Zhang: "High nuclear expression of Twist1 in the skeletal extramedullary disease of myeloma patients predicts inferior survival." in: Pathology, research and practice, Vol. 212, Issue 3, pp. 210-6, 2016 (PubMed).