Caspase 1 p20 Antikörper

Details zu Produkt Nr. ABIN6267714
Target
Reaktivität
Human, Maus, Ratte
33
19
17
Wirt
Kaninchen
34
4
Klonalität
Polyklonal
Konjugat
Unkonjugiert
5
3
2
2
2
2
2
2
2
2
2
2
1
1
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
24
13
6
2
2
1
Optionen
Immunogen The antiserum was produced against synthesized peptide derived from human Caspase 1.
Isotyp IgG
Spezifität Caspase 1 (p20,Cleaved-Asp296) Antibody detects endogenous levels of fragment of activated Caspase 1 resulting from cleavage adjacent to Asp296.
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Target
Andere Bezeichnung Caspase-1 /P20
Hintergrund

Description: Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive (PubMed:28314590).

Gene: CASP1

Molekulargewicht 20kDa
Gen-ID 834
UniProt P29466
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol..
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Caspase 1 p20 antibody (ABIN6267714) ABIN6267715 at 1/100 staining Human thyroid cancer tissue by IHC-P. The sample was fo...
Image no. 2 for anti-Caspase 1 p20 antibody (ABIN6267714) Western blot analysis of Cleaved Caspase-1 (Asp296) using Jurkat whole cell lysates