Snail Family Zinc Finger 2 (SNAI2) (pSer104) Antikörper

Details zu Produkt Nr. ABIN6267710
Target
Bindungsspezifität
pSer104
17
17
17
15
15
4
4
4
4
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Reaktivität
Human, Affe, Maus, Ratte
76
41
32
4
4
3
3
3
2
2
2
2
1
1
Wirt
Kaninchen
59
17
Klonalität
Polyklonal
Konjugat
Unkonjugiert
4
3
2
2
2
2
2
2
2
1
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
46
28
20
13
12
9
6
5
2
2
1
Optionen
Immunogen A synthesized peptide derived from human Phospho-SNAI2 (Ser104)
Isotyp IgG
Spezifität Phospho-SNAI2 (Ser104) antibody detects endogenous levels of total Phospho-SNAI2 (Ser104)
Kreuzreaktivität Human, Affe, Maus, Ratte (Rattus)
Reinigung Immunogen affinity purified
Target
Andere Bezeichnung SNAI2 (SNAI2 Antibody Abstract)
Hintergrund

Description: Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.

Gene: SNAI2

Molekulargewicht 30 kDa
Gen-ID 6591
UniProt O43623
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Bilder
Image no. 1 for anti-Snail Family Zinc Finger 2 (SNAI2) (pSer104) antibody (ABIN6267710) Western blot analysis of extracts from COS-7, using Phospho-SNAI2 (Ser104) Antibody.