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CDK4 Antikörper (Internal Region)

CDK4 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6266370
  • Target Alle CDK4 Antikörper anzeigen
    CDK4 (Cyclin-Dependent Kinase 4 (CDK4))
    Bindungsspezifität
    • 23
    • 16
    • 16
    • 9
    • 9
    • 9
    • 7
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 120
    • 76
    • 55
    • 19
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 108
    • 34
    • 2
    • 1
    Kaninchen
    Klonalität
    • 107
    • 37
    Polyklonal
    Konjugat
    • 84
    • 11
    • 11
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CDK4 Antikörper ist unkonjugiert
    Applikation
    • 122
    • 55
    • 37
    • 31
    • 21
    • 19
    • 16
    • 15
    • 14
    • 13
    • 7
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Spezifität
    CDK4 Antibody detects endogenous levels of total CDK4.
    Homologie
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human CDK4, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product CDK4 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Li, Wang, Yu, Wu, Hu, Wang, Ye: "miR-3619-5p inhibits prostate cancer cell growth by activating CDKN1A expression." in: Oncology reports, Vol. 37, Issue 1, pp. 241-248, (2017) (PubMed).

    Wang, Ge, Zhang, Chen, Hu, Li, Ye: "Targeted p53 activation by saRNA suppresses human bladder cancer cells growth and metastasis." in: Journal of experimental & clinical cancer research : CR, Vol. 35, pp. 53, (2016) (PubMed).

  • Target
    CDK4 (Cyclin-Dependent Kinase 4 (CDK4))
    Andere Bezeichnung
    CDK4 (CDK4 Produkte)
    Synonyme
    zgc:153726 antikoerper, CMM3 antikoerper, PSK-J3 antikoerper, Crk3 antikoerper, 8-6 antikoerper, CDK4 antikoerper, CDK4/6 antikoerper, CG5072 antikoerper, Cdk4/6 antikoerper, DmCdk4 antikoerper, Dmel\\CG5072 antikoerper, Pk53C antikoerper, Pk?7 antikoerper, cdk antikoerper, cdk4 antikoerper, cdk4/6 antikoerper, dCdk4 antikoerper, l(2)05428 antikoerper, l(2)0671 antikoerper, l(2)k06503 antikoerper, l(2)s4639 antikoerper, l(2)sh0671 antikoerper, xcdk4 antikoerper, cyclin-dependent kinase 4 antikoerper, cyclin dependent kinase 4 antikoerper, Cyclin-dependent kinase 4 antikoerper, cyclin-dependent kinase 4 L homeolog antikoerper, cdk4 antikoerper, CDK4 antikoerper, Cdk4 antikoerper, cdk4.L antikoerper
    Hintergrund

    Description: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

    Gene: CDK4

    Molekulargewicht
    34kDa
    Gen-ID
    1019
    UniProt
    P11802
    Pathways
    Zellzyklus, Mitotic G1-G1/S Phases, Regulation of Cell Size
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