TERT Antikörper

Produktnummer ABIN6266278

Produktdetails anti-TERT Antikörper

Target: TERT (Telomerase Reverse Transcriptase (TERT))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TERT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: TERT Antibody detects endogenous levels of total TERT.

Homologie: Pig,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human TERT

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Referenzen für anti-TERT Antikörper (ABIN6266278)

Zhang, Chen, Wang, Yang, Li, Wang, Liu, Ye: "Treatment of diabetes mellitus-induced erectile dysfunction using endothelial progenitor cells genetically modified with human telomerase reverse transcriptase." in: Oncotarget, Vol. 7, Issue 26, pp. 39302-39315, (2018) (PubMed).

Bai, Liu, Xu, Qiu, Wang, Zheng: "Expression profiles of stemness genes in gastrointestinal stromal tumor." in: Human pathology, Vol. 76, pp. 76-84, (2018) (PubMed).

Details zu TERT

Target: TERT (Telomerase Reverse Transcriptase (TERT))

Andere Bezeichnung: TERT (TERT Produkte)

Synonyme: CMM9 antikoerper, DKCA2 antikoerper, DKCB4 antikoerper, EST2 antikoerper, PFBMFT1 antikoerper, TCS1 antikoerper, TP2 antikoerper, TRT antikoerper, hEST2 antikoerper, hTRT antikoerper, chTERT antikoerper, Tert antikoerper, ATTERT antikoerper, F5E19.190 antikoerper, F5E19_190 antikoerper, telomerase reverse transcriptase antikoerper, tert antikoerper, TR antikoerper, est2 antikoerper, tcs1 antikoerper, telomerase antikoerper, tert-A antikoerper, tp2 antikoerper, trt antikoerper, xTERT antikoerper, telomerase reverse transcriptase antikoerper, Telomerase Reverse Transcriptase antikoerper, Tertp antikoerper, Telomerase catalytic subunit antikoerper, telomerase reverse transcriptase L homeolog antikoerper, TERT antikoerper, trt-1 antikoerper, Tert antikoerper, tert antikoerper, CMU_003490 antikoerper, VDBG_04487 antikoerper, GL50803_16225 antikoerper, tert.L antikoerper

Hintergrund:

Description: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.

Gene: TERT

Molekulargewicht: 120kDa

Gen-ID: 7015

UniProt: O14746

Pathways: Telomere Maintenance