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GLRA1 Antikörper (Internal Region)

GLRA1 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6266217
  • Target Alle GLRA1 Antikörper anzeigen
    GLRA1 (Glycine Receptor, alpha 1 (GLRA1))
    Bindungsspezifität
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 30
    • 15
    • 14
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 26
    • 4
    • 1
    Kaninchen
    Klonalität
    • 26
    • 4
    Polyklonal
    Konjugat
    • 20
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GLRA1 Antikörper ist unkonjugiert
    Applikation
    • 19
    • 11
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    GLRA1 Antibody detects endogenous levels of total GLRA1.
    Homologie
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human GLRA1, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product GLRA1 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:100, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    GLRA1 (Glycine Receptor, alpha 1 (GLRA1))
    Andere Bezeichnung
    GLRA1 (GLRA1 Produkte)
    Synonyme
    GLYRA1 antikoerper, HKPX1 antikoerper, STHE antikoerper, [a]Z1 antikoerper, B230397M16Rik antikoerper, nmf11 antikoerper, oscillator antikoerper, ot antikoerper, spasmodic antikoerper, spd antikoerper, glycine receptor alpha 1 antikoerper, glycine receptor, alpha 1 antikoerper, glycine receptor, alpha 1 subunit antikoerper, GLRA1 antikoerper, Glra1 antikoerper, glra1 antikoerper
    Hintergrund

    Description: Glycine receptors are ligand-gated chloride channels (PubMed:23994010, PubMed:25730860). Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:7920629, PubMed:14551753, PubMed:16144831, PubMed:22715885, PubMed:22973015, PubMed:25973519, PubMed:9009272). Channel opening is also triggered by taurine and beta-alanine (PubMed:16144831, PubMed:9009272). Channel characteristics depend on the subunit composition, heteropentameric channels are activated by lower glycine levels and display faster desensitization (PubMed:14551753). Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Channel activity is potentiated by ethanol (PubMed:25973519). Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity).

    Gene: GLRA1

    Molekulargewicht
    53kDa
    Gen-ID
    2741
    UniProt
    P23415
    Pathways
    Synaptic Membrane
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