USP10 Antikörper (N-Term)

Produktnummer ABIN6265909

Produktdetails anti-USP10 Antikörper

Target: USP10 (Ubiquitin Specific Peptidase 10 (USP10))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser USP10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Spezifität: USP10 Antibody detects endogenous levels of total USP10.

Homologie: Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human USP10, corresponding to a region within N-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu USP10

Target: USP10 (Ubiquitin Specific Peptidase 10 (USP10))

Andere Bezeichnung: USP10 (USP10 Produkte)

Synonyme: T4F9.30 antikoerper, T4F9_30 antikoerper, ubiquitin-specific protease 9 antikoerper, ubpo antikoerper, USP10 antikoerper, id:ibd1190 antikoerper, wu:fc19h08 antikoerper, wu:fc76g05 antikoerper, wu:fi11g01 antikoerper, UBPO antikoerper, 2610014N07Rik antikoerper, Uchrp antikoerper, mKIAA0190 antikoerper, usp10-A antikoerper, ubiquitin specific peptidase 10 antikoerper, universal stress protein UspA antikoerper, ubiquitin-specific protease 9 antikoerper, ubiquitin carboxyl-terminal hydrolase 10 antikoerper, ubiquitin specific peptidase 10 S homeolog antikoerper, USP10 antikoerper, RR_RS14970 antikoerper, UBP9 antikoerper, PTRG_07201 antikoerper, MGYG_06403 antikoerper, usp10 antikoerper, Usp10 antikoerper, usp10.S antikoerper

Hintergrund:

Description: Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384).

Gene: USP10

Molekulargewicht: 87 kDa

Gen-ID: 9100

UniProt: Q14694