UBA52 Antikörper

Produktnummer ABIN6265837

Produktdetails anti-UBA52 Antikörper

Target: UBA52 (Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1 (UBA52))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UBA52 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: UBA52 Antibody detects endogenous levels of total UBA52

Kreuzreaktivität: Human, Maus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human UBA52

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C.Stable for 12 months from date of receipt

Haltbarkeit: 12 months

Details zu UBA52

Target: UBA52 (Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1 (UBA52))

Andere Bezeichnung: UBA52 (UBA52 Produkte)

Synonyme: CEP52 antikoerper, HUBCEP52 antikoerper, L40 antikoerper, RPL40 antikoerper, D8Ertd21e antikoerper, Gm1863 antikoerper, Rps27a antikoerper, Ubb antikoerper, Ubc antikoerper, UBCEP2 antikoerper, UB-RPL40 antikoerper, MGC80109 antikoerper, cep52 antikoerper, hubcep52 antikoerper, rpl40 antikoerper, RPS27A antikoerper, UBB antikoerper, UBC antikoerper, wu:fa91f08 antikoerper, zgc:123344 antikoerper, UBA52 antikoerper, ubiquitin A-52 residue ribosomal protein fusion product 1 antikoerper, ubiquitin A-52 residue ribosomal protein fusion product 1 L homeolog antikoerper, UBA52 antikoerper, Uba52 antikoerper, uba52.L antikoerper, uba52 antikoerper

Hintergrund:

Description: Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair, Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation, Lys-29-linked is involved in lysosomal degradation, Lys-33-linked is involved in kinase modification, Lys-48-linked is involved in protein degradation via the proteasome, Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.

Gene: UBA52

Molekulargewicht: 15 kDa

Gen-ID: 7311

UniProt: P62987

Pathways: Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Activation of Innate immune Response, Mitotic G1-G1/S Phases, DNA Replication, Toll-Like Receptors Cascades, Synthesis of DNA, EGFR Downregulation