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TRAF6 Antikörper (Internal Region)

TRAF6 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6265707
  • Target Alle TRAF6 Antikörper anzeigen
    TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))
    Bindungsspezifität
    • 15
    • 9
    • 8
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 59
    • 32
    • 26
    • 15
    • 5
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 57
    • 5
    • 2
    Kaninchen
    Klonalität
    • 55
    • 9
    Polyklonal
    Konjugat
    • 41
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TRAF6 Antikörper ist unkonjugiert
    Applikation
    • 60
    • 18
    • 14
    • 13
    • 13
    • 11
    • 11
    • 11
    • 7
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    TRAF6 Antibody detects endogenous levels of total TRAF6.
    Homologie
    Pig,Bovine,Sheep,Rabbit,Dog,Chicken
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human TRAF6, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product TRAF6 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Zhang, Fei, Tao, Li, Shen, Wang, Liu, Xu: "Neuroprotective Effect of Modified Xijiao Dihuang Decoction against Oxygen-Glucose Deprivation and Reoxygenation-Induced Injury in PC12 Cells: Involvement of TLR4-MyD88/NF-κB Signaling Pathway." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2017, pp. 3848595, (2018) (PubMed).

  • Target
    TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))
    Andere Bezeichnung
    TRAF6 (TRAF6 Produkte)
    Synonyme
    MGC:3310 antikoerper, RNF85 antikoerper, 2310003F17Rik antikoerper, AI851288 antikoerper, C630032O20Rik antikoerper, rnf85 antikoerper, traf6 antikoerper, xtraf6 antikoerper, CG10961 antikoerper, DTRAF2 antikoerper, Dmel\\CG10961 antikoerper, TRAF antikoerper, TRAF2 antikoerper, TRAF6 antikoerper, Traf2 antikoerper, dTRAF2 antikoerper, dTRAF6 antikoerper, dTraf2 antikoerper, dtraf2 antikoerper, GB10539 antikoerper, fi15f02 antikoerper, wu:fi15f02 antikoerper, zgc:63704 antikoerper, TNF receptor associated factor 6 antikoerper, TNF receptor-associated factor 6 antikoerper, TNF receptor associated factor 6 L homeolog antikoerper, TNF-receptor-associated factor 6 antikoerper, TNF receptor associated factor 6 S homeolog antikoerper, TRAF6 antikoerper, Traf6 antikoerper, traf6.L antikoerper, traf6 antikoerper, LOC551819 antikoerper, traf6.S antikoerper
    Hintergrund

    Description: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.

    Gene: TRAF6

    Molekulargewicht
    58 kDa
    Gen-ID
    7189
    UniProt
    Q9Y4K3
    Pathways
    NF-kappaB Signalweg, T-Zell Rezeptor Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Hepatitis C, Toll-Like Receptors Cascades, Ubiquitin Proteasome Pathway
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