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TET1 Antikörper (Internal Region)

TET1 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6265522
  • Target Alle TET1 Antikörper anzeigen
    TET1 (Tet Methylcytosine Dioxygenase 1 (TET1))
    Bindungsspezifität
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    Internal Region
    Reaktivität
    Human, Maus, Ratte
    Wirt
    • 15
    • 7
    • 1
    Kaninchen
    Klonalität
    • 14
    • 9
    Polyklonal
    Konjugat
    • 19
    • 2
    • 1
    • 1
    Dieser TET1 Antikörper ist unkonjugiert
    Applikation
    • 17
    • 9
    • 5
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Spezifität
    TET1 Antibody detects endogenous levels of total TET1.
    Homologie
    Pig,Bovine,Dog
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human TET1, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product TET1 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    TET1 (Tet Methylcytosine Dioxygenase 1 (TET1))
    Andere Bezeichnung
    TET1 (TET1 Produkte)
    Synonyme
    CXXC6 antikoerper, LCX antikoerper, bA119F7.1 antikoerper, 2510010B09Rik antikoerper, AA517754 antikoerper, BB001228 antikoerper, Cxxc6 antikoerper, D10Ertd17e antikoerper, mKIAA1676 antikoerper, tet methylcytosine dioxygenase 1 antikoerper, solute carrier family 25 member 16 antikoerper, TET1 antikoerper, Tet1 antikoerper, SLC25A16 antikoerper
    Hintergrund

    Description: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, plays a more general role in chromatin regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and Polycomb-repressed genes. Involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Also involved in transcription repression of a subset of genes through recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification. Plays an important role in the tumorigenicity of glioblastoma cells. TET1-mediated production of 5hmC acts as a recruitment signal for the CHTOP-methylosome complex to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789).

    Gene: TET1

    Molekulargewicht
    235kDa
    Gen-ID
    80312
    UniProt
    Q8NFU7
    Pathways
    Stem Cell Maintenance, Warburg Effekt
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