SPAG5 Antikörper (Internal Region)

Produktnummer ABIN6265251

Produktdetails anti-SPAG5 Antikörper

Target: SPAG5 (Sperm Associated Antigen 5 (SPAG5))

Bindungsspezifität: Internal Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPAG5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: SPAG5 Antibody detects endogenous levels of total SPAG5.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human SPAG5, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu SPAG5

Target: SPAG5 (Sperm Associated Antigen 5 (SPAG5))

Andere Bezeichnung: SPAG5 (SPAG5 Produkte)

Synonyme: SPAG5 antikoerper, DEEPEST antikoerper, MAP126 antikoerper, hMAP126 antikoerper, AI874642 antikoerper, D11Bhm180e antikoerper, Deepest antikoerper, Mastrin antikoerper, S17 antikoerper, sperm associated antigen 5 antikoerper, sperm-associated antigen 5 antikoerper, SPAG5 antikoerper, LOC739263 antikoerper, Spag5 antikoerper

Hintergrund:

Description: Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457).

Gene: SPAG5

Molekulargewicht: 134 kDa

Gen-ID: 10615

UniProt: Q96R06

Pathways: M Phase