SRSF1 Antikörper

Produktnummer ABIN6265029

Produktdetails anti-SRSF1 Antikörper

Target: SRSF1 (serine/arginine-Rich Splicing Factor 1 (SRSF1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SRSF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Spezifität: SFRS1 Antibody detects endogenous levels of total SFRS1

Kreuzreaktivität: Human, Maus, Ratte (Rattus)

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human SFRS1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000 IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C.Stable for 12 months from date of receipt

Haltbarkeit: 12 months

Details zu SRSF1

Target: SRSF1 (serine/arginine-Rich Splicing Factor 1 (SRSF1))

Andere Bezeichnung: SFRS1 (SRSF1 Produkte)

Synonyme: ASF antikoerper, SF2 antikoerper, SF2p33 antikoerper, SFRS1 antikoerper, SRp30a antikoerper, 1110054N12Rik antikoerper, 5730507C05Rik antikoerper, 6330415C05Rik antikoerper, AI482334 antikoerper, AW491331 antikoerper, Asf antikoerper, Sf2 antikoerper, Sfrs1 antikoerper, DKFZp469K2419 antikoerper, sfrs1 antikoerper, sfrs1b antikoerper, wu:fb80g05 antikoerper, zgc:111894 antikoerper, zgc:65898 antikoerper, zgc:76897 antikoerper, asf antikoerper, sf2 antikoerper, sf2p33 antikoerper, srp30a antikoerper, sfrs1a antikoerper, sfrs1l antikoerper, wu:fb52g10 antikoerper, wu:fb97g12 antikoerper, zgc:66146 antikoerper, serine and arginine rich splicing factor 1 antikoerper, serine/arginine-rich splicing factor 1 antikoerper, serine/arginine-rich splicing factor 1b antikoerper, serine/arginine-rich splicing factor 1 L homeolog antikoerper, serine/arginine-rich splicing factor 1a antikoerper, SRSF1 antikoerper, Srsf1 antikoerper, srsf1b antikoerper, srsf1.L antikoerper, srsf1a antikoerper

Hintergrund:

Description: Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway.

Gene: SRSF1

Molekulargewicht: 28kDa

Gen-ID: 6426

UniProt: Q07955

Pathways: Ribonucleoprotein Complex Subunit Organization