RYR2 Antikörper (Internal Region)

Produktnummer ABIN6264892

Produktdetails anti-RYR2 Antikörper

Target: RYR2 (Ryanodine Receptor 2 (Cardiac) (RYR2))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RYR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: RYR2 Antibody detects endogenous levels of total RYR2.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human RYR2, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol. .

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu RYR2

Target: RYR2 (Ryanodine Receptor 2 (Cardiac) (RYR2))

Andere Bezeichnung: RYR2 (RYR2 Produkte)

Synonyme: RYR2 antikoerper, ARVC2 antikoerper, ARVD2 antikoerper, RYR-2 antikoerper, RyR antikoerper, VTSIP antikoerper, 9330127I20Rik antikoerper, ryanodine receptor 2 antikoerper, ryanodine receptor 2, cardiac antikoerper, RYR2 antikoerper, Ryr2 antikoerper

Hintergrund:

Description: Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca2+ levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.

Gene: RYR2

Molekulargewicht: 564 kDa

Gen-ID: 6262

UniProt: Q92736

Pathways: Myometrial Relaxation and Contraction