ROS1 Antikörper (C-Term)

Produktnummer ABIN6264807

Produktdetails anti-ROS1 Antikörper

Target: ROS1 (C-Ros Oncogene 1 , Receptor tyrosine Kinase (ROS1))

Bindungsspezifität: C-Term

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ROS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: ROS Antibody detects endogenous levels of total ROS.

Homologie: Pig,Horse,Sheep

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ROS, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu ROS1

Target: ROS1 (C-Ros Oncogene 1 , Receptor tyrosine Kinase (ROS1))

Andere Bezeichnung: ROS1 (ROS1 Produkte)

Synonyme: MCF3 antikoerper, ROS antikoerper, c-ros-1 antikoerper, ROS1C antikoerper, Ros-1 antikoerper, c-ros antikoerper, ROS proto-oncogene 1, receptor tyrosine kinase antikoerper, ROS proto-oncogene 1 , receptor tyrosine kinase antikoerper, Ros1 proto-oncogene antikoerper, ROS1 antikoerper, Ros1 antikoerper

Hintergrund:

Description: Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.

Gene: ROS1

Molekulargewicht: 263kDa

Gen-ID: 6098

UniProt: P08922

Pathways: RTK Signalweg