ROBO1 Antikörper (Internal Region)
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- Target Alle ROBO1 Antikörper anzeigen
- ROBO1 (Roundabout, Axon Guidance Receptor, Homolog 1 (ROBO1))
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Bindungsspezifität
- Internal Region
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser ROBO1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Spezifität
- ROBO1 Antibody detects endogenous levels of total ROBO1.
- Homologie
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human ROBO1, corresponding to a region within the internal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product ROBO1 Primärantikörper
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- Applikationshinweise
- WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- ROBO1 (Roundabout, Axon Guidance Receptor, Homolog 1 (ROBO1))
- Andere Bezeichnung
- ROBO1 (ROBO1 Produkte)
- Synonyme
- DUTT1 antikoerper, SAX3 antikoerper, AW494633 antikoerper, AW742721 antikoerper, Gm310 antikoerper, ROBO1 antikoerper, dutt1 antikoerper, roundabout antikoerper, sax3 antikoerper, MGC122264 antikoerper, roundabout-1 antikoerper, roundabout guidance receptor 1 antikoerper, roundabout, axon guidance receptor, homolog 1 (Drosophila) antikoerper, roundabout guidance receptor 1 L homeolog antikoerper, ROBO1 antikoerper, Robo1 antikoerper, robo1 antikoerper, robo1.L antikoerper
- Hintergrund
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Description: Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B, inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development (By similarity).
Gene: ROBO1
- Molekulargewicht
- 181 kDa
- Gen-ID
- 6091
- UniProt
- Q9Y6N7
- Pathways
- Positive Regulation of Endopeptidase Activity
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