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RNF20 Antikörper (Internal Region)

RNF20 Reaktivität: Human, Maus WB, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6264788
  • Target Alle RNF20 Antikörper anzeigen
    RNF20 (Ring Finger Protein 20 (RNF20))
    Bindungsspezifität
    • 7
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 61
    • 33
    • 20
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Human, Maus
    Wirt
    • 55
    • 6
    Kaninchen
    Klonalität
    • 48
    • 13
    Polyklonal
    Konjugat
    • 27
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser RNF20 Antikörper ist unkonjugiert
    Applikation
    • 47
    • 21
    • 13
    • 7
    • 6
    • 6
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    RNF20 Antibody detects endogenous levels of total RNF20.
    Homologie
    Pig,Bovine,Horse,Rabbit,Dog,Chicken
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human RNF20, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product RNF20 Primärantikörper
  • Applikationshinweise
    WB 1:1000-3000, IF/ICC, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    RNF20 (Ring Finger Protein 20 (RNF20))
    Andere Bezeichnung
    RNF20 (RNF20 Produkte)
    Synonyme
    4833430L21Rik antikoerper, AW540162 antikoerper, C79397 antikoerper, mKIAA4116 antikoerper, BRE1 antikoerper, BRE1A antikoerper, hBRE1 antikoerper, ring finger protein 20 antikoerper, RNF20 antikoerper, Rnf20 antikoerper
    Hintergrund

    Description: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B, reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation.

    Gene: RNF20

    Molekulargewicht
    114kDa
    Gen-ID
    56254
    UniProt
    Q5VTR2
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