Retinoic Acid Receptor gamma Antikörper

Produktnummer ABIN6264704

Produktdetails anti-Retinoic Acid Receptor gamma Antikörper

Target: Retinoic Acid Receptor gamma (RARG) (Retinoic Acid Receptor, gamma (RARG))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Retinoic Acid Receptor gamma Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: Retinoic Acid Receptor / Antibody detects endogenous levels of Retinoic Acid Receptor /

Kreuzreaktivität: Human, Maus, Ratte (Rattus)

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human Retinoic Acid Receptor /

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C.Stable for 12 months from date of receipt

Haltbarkeit: 12 months

Details zu Retinoic Acid Receptor gamma

Target: Retinoic Acid Receptor gamma (RARG) (Retinoic Acid Receptor, gamma (RARG))

Andere Bezeichnung: Retinoic Acid Receptor (RARG Produkte)

Synonyme: NR1B3 antikoerper, RARC antikoerper, AI385767 antikoerper, Nr1b3 antikoerper, RARD antikoerper, RARgamma2 antikoerper, RARG antikoerper, etID309710.23 antikoerper, etID33387.23 antikoerper, rarg antikoerper, rarg2 antikoerper, wu:fb01e02 antikoerper, wu:fb01f03 antikoerper, wu:fc35a09 antikoerper, nr1b3 antikoerper, RARgamma-B antikoerper, retinoic acid receptor gamma antikoerper, retinoic acid receptor, gamma antikoerper, retinoic acid receptor gamma a antikoerper, retinoic acid receptor gamma S homeolog antikoerper, retinoic acid receptor, gamma b antikoerper, RARG antikoerper, Rarg antikoerper, rarga antikoerper, rarg.S antikoerper, rargb antikoerper

Hintergrund:

Description: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).

Gene: RARA

Molekulargewicht: 50kDa

Gen-ID: 5914

UniProt: P10276, P10826

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Cell Size