PTPRB Antikörper (N-Term)

Produktnummer ABIN6264522

Produktdetails anti-PTPRB Antikörper

Target: PTPRB (Protein tyrosine Phosphatase, Receptor Type, B (PTPRB))

Bindungsspezifität: N-Term

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTPRB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Spezifität: PTPRB Antibody detects endogenous levels of total PTPRB.

Homologie: Pig,Rabbit

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human PTPRB, corresponding to a region within N-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu PTPRB

Target: PTPRB (Protein tyrosine Phosphatase, Receptor Type, B (PTPRB))

Andere Bezeichnung: PTPRB (PTPRB Produkte)

Synonyme: PTPRB antikoerper, HPTP-BETA antikoerper, HPTPB antikoerper, PTPB antikoerper, R-PTP-BETA antikoerper, VEPTP antikoerper, 3230402H02Rik antikoerper, C130094E24 antikoerper, Ptpz antikoerper, Rptpb antikoerper, VE-PTP antikoerper, Veptp antikoerper, protein tyrosine phosphatase, receptor type B antikoerper, receptor-type tyrosine-protein phosphatase beta antikoerper, protein tyrosine phosphatase, receptor type, B antikoerper, PTPRB antikoerper, LOC100380677 antikoerper, Ptprb antikoerper

Hintergrund:

Description: Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).

Gene: PTPRB

Molekulargewicht: 224kDa

Gen-ID: 5787

UniProt: P23467