PRKRA Antikörper (Internal Region)

Produktnummer ABIN6264430

Produktdetails anti-PRKRA Antikörper

Target: PRKRA (Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator (PRKRA))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRKRA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: PRKRA Antibody detects endogenous levels of total PRKRA.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human PRKRA, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu PRKRA

Target: PRKRA (Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator (PRKRA))

Andere Bezeichnung: PRKRA (PRKRA Produkte)

Synonyme: PRKRA antikoerper, AV120107 antikoerper, PRK antikoerper, Pact antikoerper, RAX antikoerper, lear antikoerper, DYT16 antikoerper, PACT antikoerper, im:7151758 antikoerper, zgc:162619 antikoerper, dyt16 antikoerper, pact antikoerper, prkra-a antikoerper, prkra-b antikoerper, rax antikoerper, rbpa antikoerper, protein activator of interferon induced protein kinase EIF2AK2 antikoerper, protein kinase, interferon inducible double stranded RNA dependent activator antikoerper, protein kinase, interferon-inducible double stranded RNA dependent activator antikoerper, protein activator of interferon induced protein kinase EIF2AK2 L homeolog antikoerper, PRKRA antikoerper, Prkra antikoerper, prkra antikoerper, prkra.L antikoerper

Hintergrund:

Description: Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity).

Gene: PRKRA

Molekulargewicht: 34kDa

Gen-ID: 8575

UniProt: O75569

Pathways: Regulatorische RNA Pathways