NUDT21 Antikörper (Internal Region)

Produktnummer ABIN6263764

Produktdetails anti-NUDT21 Antikörper

Target: NUDT21 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 21 (NUDT21))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NUDT21 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: NUDT21 Antibody detects endogenous levels of total NUDT21.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human NUDT21, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu NUDT21

Target: NUDT21 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 21 (NUDT21))

Andere Bezeichnung: NUDT21 (NUDT21 Produkte)

Synonyme: CFIM25 antikoerper, CPSF5 antikoerper, 25kDa antikoerper, 3110048P04Rik antikoerper, 5730530J16Rik antikoerper, AU014860 antikoerper, AW549947 antikoerper, Cpsf5 antikoerper, zgc:63966 antikoerper, cpsf5 antikoerper, An16g01870 antikoerper, AO090003001316 antikoerper, Afu5g02030 antikoerper, T9L24.30 antikoerper, T9L24_30 antikoerper, atnudt21 antikoerper, nudix hydrolase homolog 21 antikoerper, nudix hydrolase 21 antikoerper, nudix (nucleoside diphosphate linked moiety X)-type motif 21 antikoerper, nudix hydrolase 21 L homeolog antikoerper, cleavage and polyadenylation specificity factor subunit 5 antikoerper, cleavage and polyadenylation specific factor 5 antikoerper, autocrine motility factor receptor antikoerper, nudix hydrolase homolog 21 antikoerper, NUDT21 antikoerper, Nudt21 antikoerper, nudt21 antikoerper, nudt21.L antikoerper, ANI_1_1518144 antikoerper, AOR_1_2312154 antikoerper, PTRG_11035 antikoerper, PAAG_04662 antikoerper, MCYG_02022 antikoerper, VDBG_06706 antikoerper, MGYG_04057 antikoerper, cpsf5 antikoerper, PGTG_05353 antikoerper, Tsp_03672 antikoerper, LOC732888 antikoerper, AFUA_5G02030 antikoerper, NFIA_040090 antikoerper, ACLA_003240 antikoerper, CC1G_07993 antikoerper, PMAA_039710 antikoerper, AFLA_025180 antikoerper, TSTA_079060 antikoerper, BDBG_01565 antikoerper, TERG_04393 antikoerper

Hintergrund:

Description: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:15937220, PubMed:17024186, PubMed:17098938, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:17024186). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:17098938, PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:17098938, PubMed:20695905, PubMed:29276085). NUDT21/CPSF5 activates indirectly the mRNA 3'-processing machinery by recruiting CPSF6 and/or CPSF7 (PubMed:29276085). Binds to 5'-UGUA-3' elements localized upstream of pA signals that act as enhancers of pre-mRNA 3'-end processing (PubMed:8626397, PubMed:14690600, PubMed:15169763, PubMed:17024186, PubMed:22813749, PubMed:20479262). The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA (PubMed:20479262, PubMed:21295486). Plays a role in somatic cell fate transitions and pluripotency by regulating widespread changes in gene expression through an APA-dependent function (By similarity). Binds to chromatin (By similarity). Binds to, but does not hydrolyze mono- and di-adenosine nucleotides (PubMed:18445629).

Gene: NUDT21

Molekulargewicht: 26 kDa

Gen-ID: 11051

UniProt: O43809