NPHP1 Antikörper (Internal Region)

Produktnummer ABIN6263699

Produktdetails anti-NPHP1 Antikörper

Target: NPHP1 (Nephronophthisis 1 (Juvenile) (NPHP1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NPHP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: NPHP1 Antibody detects endogenous levels of total NPHP1.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human NPHP1, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu NPHP1

Target: NPHP1 (Nephronophthisis 1 (Juvenile) (NPHP1))

Andere Bezeichnung: NPHP1 (NPHP1 Produkte)

Synonyme: JBTS4 antikoerper, NPH1 antikoerper, SLSN1 antikoerper, nephrocystin-1 antikoerper, NPHP1 antikoerper, im:7162391 antikoerper, wu:fi59g07 antikoerper, zgc:152930 antikoerper, Nphp1 antikoerper, nephrocystin 1 antikoerper, nephronophthisis 1 (juvenile) homolog (human) antikoerper, nephronophthisis 1 (juvenile) L homeolog antikoerper, nephronophthisis 1 antikoerper, nephrocystin-1 antikoerper, NPHP1 antikoerper, Nphp1 antikoerper, nphp1.L antikoerper, nphp1 antikoerper, LOC100725987 antikoerper

Hintergrund:

Description: Together with BCAR1 it may play a role in the control of epithelial cell polarity. Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling. May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina development. In connecting photoreceptor cilia influences the movement of some IFT proteins such as IFT88 and WDR19. Involved in spermatogenesis (By similarity).

Gene: NPHP1

Molekulargewicht: 83 kDa

Gen-ID: 4867

UniProt: O15259