NPC2 Antikörper (N-Term)

Produktnummer ABIN6263698

Produktdetails anti-NPC2 Antikörper

Target: NPC2 (Niemann-Pick Disease, Type C2 (NPC2))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NPC2 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: NPC2 Antibody detects endogenous levels of total NPC2.

Homologie: Horse,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human NPC2, corresponding to a region within N-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu NPC2

Target: NPC2 (Niemann-Pick Disease, Type C2 (NPC2))

Andere Bezeichnung: NPC2 (NPC2 Produkte)

Synonyme: 2700012J19Rik antikoerper, AA408070 antikoerper, AU045843 antikoerper, HE1 antikoerper, EDDM1 antikoerper, re1 antikoerper, CE1 antikoerper, EPI-1 antikoerper, cb292 antikoerper, sb:cb292 antikoerper, NPC intracellular cholesterol transporter 2 antikoerper, Niemann-Pick disease, type C2 antikoerper, Npc2 antikoerper, NPC2 antikoerper, npc2 antikoerper

Hintergrund:

Description: Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport.

Gene: NPC2

Molekulargewicht: 17kDa

Gen-ID: 10577

UniProt: P61916

Pathways: SARS-CoV-2 Protein Interaktom