NFKBIZ Antikörper (Internal Region)

Produktnummer ABIN6263630

Produktdetails anti-NFKBIZ Antikörper

Target: NFKBIZ (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, zeta (NFKBIZ))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NFKBIZ Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: NFKBIZ Antibody detects endogenous levels of total NFKBIZ.

Homologie: Bovine,Horse,Sheep,Rabbit

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human NFKBIZ, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu NFKBIZ

Target: NFKBIZ (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, zeta (NFKBIZ))

Andere Bezeichnung: NFKBIZ (NFKBIZ Produkte)

Synonyme: RGD1310834 antikoerper, NFKBIZ antikoerper, MAIL antikoerper, AA408868 antikoerper, INAP antikoerper, Mail antikoerper, IKBZ antikoerper, NFKB inhibitor zeta antikoerper, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta antikoerper, nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta antikoerper, Nfkbiz antikoerper, NFKBIZ antikoerper, nfkbiz antikoerper

Hintergrund:

Description: Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity).

Gene: NFKBIZ

Molekulargewicht: 64 kDa

Gen-ID: 64332

UniProt: Q9BYH8

Pathways: NF-kappaB Signalweg