NAT10 Antikörper (Internal Region)

Produktnummer ABIN6263520

Produktdetails anti-NAT10 Antikörper

Target: NAT10 (N-Acetyltransferase 10 (GCN5-Related) (NAT10))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NAT10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: NAT10 Antibody detects endogenous levels of total NAT10.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human NAT10, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu NAT10

Target: NAT10 (N-Acetyltransferase 10 (GCN5-Related) (NAT10))

Andere Bezeichnung: NAT10 (NAT10 Produkte)

Synonyme: ALP antikoerper, NET43 antikoerper, AI429152 antikoerper, zgc:66119 antikoerper, DDBDRAFT_0190093 antikoerper, DDBDRAFT_0234062 antikoerper, DDB_0190093 antikoerper, DDB_0234062 antikoerper, RGD1306717 antikoerper, N-acetyltransferase 10 antikoerper, N-acetyltransferase 10 (GCN5-related) antikoerper, ribosome biogenesis ATPase (predicted) antikoerper, hypothetical protein antikoerper, N-acetyltransferase 10 (GCN5-related) L homeolog antikoerper, NAT10 antikoerper, Nat10 antikoerper, nat10 antikoerper, CC1G_12871 antikoerper, MCYG_05927 antikoerper, PITG_19671 antikoerper, MGYG_06040 antikoerper, SPAC20G8.09c antikoerper, nat10.L antikoerper

Hintergrund:

Description: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs (PubMed:25411247, PubMed:25653167). Catalyzes the formation of N4-acetylcytidine (ac4C) at position 1842 in 18S rRNA (PubMed:25411247). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25411247, PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMBD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). Can acetylate both histones and microtubules (PubMed:14592445, PubMed:17631499, PubMed:19303003). Histone acetylation may regulate transcription and mitotic chromosome de-condensation (PubMed:17631499). Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (PubMed:14592445, PubMed:18082603). Acetylates alpha-tubulin, which may affect microtubule stability and cell division (PubMed:19303003).

Gene: NAT10

Molekulargewicht: 116 kDa

Gen-ID: 55226

UniProt: Q9H0A0