MPHOSPH8 Antikörper (Internal Region)

Produktnummer ABIN6263338

Produktdetails anti-MPHOSPH8 Antikörper

Target: MPHOSPH8 (M-Phase phosphoprotein 8 (MPHOSPH8))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MPHOSPH8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: MPHOSPH8 Antibody detects endogenous levels of total MPHOSPH8.

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human MPHOSPH8, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu MPHOSPH8

Target: MPHOSPH8 (M-Phase phosphoprotein 8 (MPHOSPH8))

Andere Bezeichnung: MPHOSPH8 (MPHOSPH8 Produkte)

Synonyme: HSMPP8 antikoerper, TWA3 antikoerper, mpp8 antikoerper, 1500035L22Rik antikoerper, 4930548G07Rik antikoerper, AU040635 antikoerper, Ab2-008 antikoerper, RGD1305133 antikoerper, M-phase phosphoprotein 8 antikoerper, MPHOSPH8 antikoerper, Mphosph8 antikoerper

Hintergrund:

Description: Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3 (PubMed:26022416). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites, these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592).

Gene: MPHOSPH8

Molekulargewicht: 97 kDa

Gen-ID: 54737

UniProt: Q99549