MAP4K6 Antikörper (Internal Region)

Produktnummer ABIN6263255

Produktdetails anti-MAP4K6 Antikörper

Target: MAP4K6 (MINK1) (Misshapen-Like Kinase 1 (MINK1))

Bindungsspezifität: Internal Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAP4K6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Spezifität: MINK1 Antibody detects endogenous levels of total MINK1.

Homologie: Pig,Zebrafish,Bovine,Horse,Dog,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human MINK1, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu MAP4K6

Target: MAP4K6 (MINK1) (Misshapen-Like Kinase 1 (MINK1))

Andere Bezeichnung: MINK1 (MINK1 Produkte)

Synonyme: MINK1 antikoerper, MINK antikoerper, B55 antikoerper, MAP4K6 antikoerper, YSK2 antikoerper, ZC3 antikoerper, hMINK antikoerper, hMINKbeta antikoerper, MEKKK 6 antikoerper, Map4k6 antikoerper, RP23-122P1.6 antikoerper, Ysk2 antikoerper, misshapen like kinase 1 antikoerper, misshapen-like kinase 1 antikoerper, misshapen-like kinase 1 (zebrafish) antikoerper, MINK1 antikoerper, Mink1 antikoerper

Hintergrund:

Description: Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.

Gene: MINK1

Molekulargewicht: 150kDa

Gen-ID: 50488

UniProt: Q8N4C8

Pathways: Synaptic Membrane