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CSF1R Antikörper (Internal Region)

CSF1R Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6263037
  • Target Alle CSF1R Antikörper anzeigen
    CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))
    Bindungsspezifität
    • 20
    • 20
    • 18
    • 16
    • 16
    • 15
    • 14
    • 11
    • 9
    • 8
    • 7
    • 7
    • 6
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 197
    • 140
    • 97
    • 17
    • 8
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 224
    • 30
    • 9
    • 3
    • 2
    Kaninchen
    Klonalität
    • 226
    • 41
    • 1
    Polyklonal
    Konjugat
    • 95
    • 27
    • 15
    • 15
    • 14
    • 11
    • 10
    • 10
    • 9
    • 9
    • 9
    • 9
    • 5
    • 5
    • 5
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CSF1R Antikörper ist unkonjugiert
    Applikation
    • 175
    • 107
    • 89
    • 68
    • 50
    • 26
    • 24
    • 21
    • 12
    • 6
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    MCSF Receptor Antibody detects endogenous levels of total MCSF Receptor.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human MCSF Receptor, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product CSF1R Primärantikörper
  • Applikationshinweise
    WB: 1:500-1:3000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))
    Andere Bezeichnung
    CSF1R (CSF1R Produkte)
    Synonyme
    AI323359 antikoerper, CD115 antikoerper, CSF-1R antikoerper, Csfmr antikoerper, Fim-2 antikoerper, Fms antikoerper, M-CSF-R antikoerper, M-CSFR antikoerper, C-FMS antikoerper, CSFR antikoerper, FIM2 antikoerper, FMS antikoerper, HDLS antikoerper, PDGFRB antikoerper, MGC89146 antikoerper, CSF-1-R antikoerper, c-fms antikoerper, mrfms antikoerper, CSF1 antikoerper, M-CSF antikoerper, csf1r antikoerper, fms antikoerper, panther antikoerper, colony stimulating factor 1 receptor antikoerper, macrophage colony-stimulating factor receptor antikoerper, colony stimulating factor 1 receptor, a antikoerper, Csf1r antikoerper, CSF1R antikoerper, m-csfr antikoerper, csf1r antikoerper, csf1ra antikoerper
    Hintergrund

    Description: Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor.

    Gene: CSF1R

    Molekulargewicht
    108kDa
    Gen-ID
    1436
    UniProt
    P07333
    Pathways
    RTK Signalweg, Inositol Metabolic Process, Cell-Cell Junction Organization
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