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LRP2 Antikörper (Internal Region)

LRP2 Reaktivität: Human, Maus, Ratte ELISA, IHC, WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6263006
  • Target Alle LRP2 Antikörper anzeigen
    LRP2 (Low Density Lipoprotein Receptor-Related Protein 2 (LRP2))
    Bindungsspezifität
    • 16
    • 8
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 55
    • 31
    • 15
    • 4
    • 4
    Human, Maus, Ratte
    Wirt
    • 53
    • 2
    Kaninchen
    Klonalität
    • 53
    • 3
    Polyklonal
    Konjugat
    • 18
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser LRP2 Antikörper ist unkonjugiert
    Applikation
    • 21
    • 17
    • 16
    • 14
    • 13
    • 7
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
    Spezifität
    Lrp2 / Megalin Antibody detects endogenous levels of total Lrp2 / Megalin.
    Homologie
    Horse
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human Lrp2 / Megalin, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product LRP2 Primärantikörper
  • Applikationshinweise
    WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    LRP2 (Low Density Lipoprotein Receptor-Related Protein 2 (LRP2))
    Andere Bezeichnung
    LRP2 (LRP2 Produkte)
    Synonyme
    im:680590 antikoerper, lrp2 antikoerper, dbs antikoerper, gp330 antikoerper, megalin antikoerper, DBS antikoerper, GP330 antikoerper, AI315343 antikoerper, AW536255 antikoerper, D230004K18Rik antikoerper, Gp330 antikoerper, Megalin antikoerper, LDL receptor related protein 2 antikoerper, low density lipoprotein receptor-related protein 2a antikoerper, low density lipoprotein receptor-related protein 2 antikoerper, low-density lipoprotein receptor-related protein 2 antikoerper, LDL receptor related protein 2 L homeolog antikoerper, LRP2 antikoerper, lrp2a antikoerper, LRP2.3 antikoerper, lrp2.L antikoerper, LOC100183506 antikoerper, lrp2 antikoerper, Lrp2 antikoerper
    Hintergrund

    Description: Multiligand endocytic receptor (By similarity). Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). In the kidney, mediates the tubular uptake and clearance of leptin (By similarity). Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity). Endocytosis of leptin in neuronal cells is required for hypothalamic leptin signaling and leptin-mediated regulation of feeding and body weight (By similarity). Mediates endocytosis and subsequent lysosomal degradation of CST3 in kidney proximal tubule cells (By similarity). Mediates renal uptake of 25-hydroxyvitamin D3 in complex with the vitamin D3 transporter GC/DBP (By similarity). Mediates renal uptake of metallothionein-bound heavy metals (PubMed:15126248). Together with CUBN, mediates renal reabsorption of myoglobin (By similarity). Mediates renal uptake and subsequent lysosomal degradation of APOM (By similarity). Plays a role in kidney selenium homeostasis by mediating renal endocytosis of selenoprotein SEPP1 (By similarity). Mediates renal uptake of the antiapoptotic protein BIRC5/survivin which may be important for functional integrity of the kidney (PubMed:23825075). Mediates renal uptake of matrix metalloproteinase MMP2 in complex with metalloproteinase inhibitor TIMP1 (By similarity). Mediates endocytosis of Sonic hedgehog protein N-product (ShhN), the active product of SHH (By similarity). Also mediates ShhN transcytosis (By similarity). In the embryonic neuroepithelium, mediates endocytic uptake and degradation of BMP4, is required for correct SHH localization in the ventral neural tube and plays a role in patterning of the ventral telencephalon (By similarity). Required at the onset of neurulation to sequester SHH on the apical surface of neuroepithelial cells of the rostral diencephalon ventral midline and to control PTCH1-dependent uptake and intracellular trafficking of SHH (By similarity). During neurulation, required in neuroepithelial cells for uptake of folate bound to the folate receptor FOLR1 which is necessary for neural tube closure (By similarity). In the adult brain, negatively regulates BMP signaling in the subependymal zone which enables neurogenesis to proceed (By similarity). In astrocytes, mediates endocytosis of ALB which is required for the synthesis of the neurotrophic factor oleic acid (By similarity). Involved in neurite branching (By similarity). During optic nerve development, required for SHH-mediated migration and proliferation of oligodendrocyte precursor cells (By similarity). Mediates endocytic uptake and clearance of SHH in the retinal margin which protects retinal progenitor cells from mitogenic stimuli and keeps them quiescent (By similarity). Plays a role in reproductive organ development by mediating uptake in reproductive tissues of androgen and estrogen bound to the sex hormone binding protein SHBG (By similarity). Mediates endocytosis of angiotensin-2 (By similarity). Also mediates endocytosis of angiotensis 1-7 (By similarity). Binds to the complex composed of beta-amyloid protein 40 and CLU/APOJ and mediates its endocytosis and lysosomal degradation (By similarity). Required for embryonic heart development (By similarity). Required for normal hearing, possibly through interaction with estrogen in the inner ear (By similarity).

    Gene: LRP2

    Molekulargewicht
    280kDa
    Gen-ID
    4036
    UniProt
    P98164
    Pathways
    Metabolism of Steroid Hormones and Vitamin D, Thyroid Hormone Synthesis, Hormone Transport
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