LAT Antikörper (Internal Region)

Produktnummer ABIN6262916

Produktdetails anti-LAT Antikörper

Target: LAT (Linker For Activation of T Cells (LAT))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LAT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Spezifität: LAT Antibody detects endogenous levels of total LAT.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human LAT, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, IF/ICC 1:200-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu LAT

Target: LAT (Linker For Activation of T Cells (LAT))

Andere Bezeichnung: LAT (LAT Produkte)

Synonyme: LAT antikoerper, lat antikoerper, LAT1 antikoerper, pp36 antikoerper, linker for activation of T-cells antikoerper, linker for activation of T cells antikoerper, LAT antikoerper, lat antikoerper, Lat antikoerper

Hintergrund:

Description: Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

Gene: LAT

Molekulargewicht: 28kDa

Gen-ID: 27040

UniProt: O43561

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung